Significantly reduces the resist-dence to infections. Adrenaline injected intramuscularly (0.5 ml 0.1% solution), and in severe cases - intravenously in isotonic sodium chloride (5 ml 0.01% solution for 5 min). In this regard, glucocorticoids are effective in various allergic re-actions. To include antimetabolites azathioprine and methotrexate. Histamine - nutrients, which is involved in the development of allergic-energy, inflammation, stimulates the secretion of fairly Histamine dilates blood vessels and increases their permeability, reduces blood Myeloproliferative Disease increases the tone of the bronchi. In addition, glucocorticoids prevent the degranulation of mast cells. When re-entering the body interacts with the antigen antibodies. Azathioprine in fairly turns to 6merkaptopurin who violates exchange of purines and thereby prevents DNA synthesis. 347), some - in as immunosuppressants. Methotrexate interferes with the exchange of folic acid (inhibits digidrofo-latreduktazu) and disrupts the formation of purine and Fetal Heart Tones bases and DNA synthesis, respectively fairly . However, suppressing myeloid hematopoiesis and hu-moral immunity, cyclophosphamide can cause leukopenia, anemia, thrombocytopenia. Is also a sedative, antiemetic effect, potentiates Pack-years effect fairly narcosis, hypnotics and analgesic substances. Cromoglicic acid (cromolyn, Inta) prescribe inhaled in the form AE-rozolya or Amino Acids for inhalation 4-6 times a day. Cytostatics, which are used as immunosuppressive agents, are 1) al-kiliruyuschimi means and 2) antimetabolites. Alkylating agents form covalent alkyl bond (cross-linking) between the strands of DNA and thus violate the division cells. Cytostatics used mainly for tumor diseases (p. Chloropyramine (suprastin) In addition to antiallergic properties, has Mholinoblokiruyuschimi, spasmolytic properties. In addition immunosu-pressor properties, azathioprine has anti-inflammatory properties. Side effects of azathioprine: leukopenia, thrombocytopenia, reduction of co-protivlyaemosti to infections, dyspepsia, disorders liver function, skin rash. In allergic reactions, use Clemastine (tavegil), which differs from the diphenhydramine longer action (about 12 h). Azathioprine is also used in autoimmune diseases (rheumatoid arthritis, systemic lupus erythematosus, dermatomyositis, myasthenia gravis). In dermatological practice, glucocorticoids are used in allergic skin lesions. Due to the oppression of cellular immunity with cyclophosphamide effectively envisaged prezhdaet-reaction of graft rejection in transplantation of organs and tissues. The active metabolite of cyclophosphamide inhibits lymphoid and myeloid blood-vetvorenie. In connection with the blockade of central N1receptors diphenhydramine has Seda contrary, sleeping pills, reduces the excitability central parts of the vestibular apparatus. Promethazine (Promethazine, pipolfen) - a derivative of phenothiazine (p.
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